George Uppington was born in 1879 at Tredegar in Monmouthshire, Wales to William Uppington and Mary. His father was a coal miner and George too worked in the mines for a short time.
In the 1901 census he is listed as a 'Theological Scholar', at Western College, Mannamead, Plymouth.
During the First World War the Rev Uppington served in the Royal Army Chaplain's Department
In 1935 Uppington became rector of St. Thomas and St. Clement with St. Michael and St. Swithun, Winchester.